Serviceeinheit Massenspektrometrie 

MS-service titel
The Mass Spectrometry Service Unit is an infrastructure facility of Faculty 14 at Goethe University. The working groups of the Goethe University Frankfurt are entitled to use it (see also user regulations).
The Mass Spectrometry (MS) Service Frankfurt operates as a centralized research infrastructure at Campus Riedberg, providing cutting-edge analytical capabilities to academic collaborators. Our unit is structured into two distinct, methodologically complementary service platforms:  Small Molecule Service and Nucleic Acid-MS Core Facility

Aktuelle Informationen

Small Molecule Service

Focus: 
  • Analysis of drugs, natural products, and synthetic small molecules.
Core Methods & Instrumentation:
  • ESI-qTOF and Orbitrap-based high-resolution MS
  • MALDI-TOF/TOF
  • TLC-MS and ESI-MS
Applications:
  • Structure confirmation
  • Compound QC and purity assessment
Access & Contact:
  • Open to all research groups at Goethe University and RMU
  • Submission via the online LOGS service
  • Managed by Dr. Steffen Kaiser


Nucleic Acid-MS Core Facility

Focus: 
  • Mass spectrometric analysis of (modified) nucleosides, oligonucleotides, and RNA.
Core Methods & Instrumentation:
  • UHPLC-QQQ-MS for quantitative nucleoside profiling 
  • MALDI-MS of RNA smaller 30 nts
  • High-resolution Orbitrap Tribrid MS for oligonucleotide fragmentation
  • Shotgun RNomics (from 2025)
Applications: 
  • Epitranscriptomic profiling (modification mapping)
  • Oligonucleotide integrity and sequence confirmation
  • RNA degradation and modification dynamics
  • Method development for RNA therapeutics
Access & Contact: 
  • Project-based access via application form
  • Priority for SFB1309, TRR440, SCALE, and HRPC collaborators
  • Managed by Prof. Dr. Stefanie Kaiser